Cymbalta overdose dosage. It was one of Eli Lilly’s most profitable drugs.

Cymbalta overdose dosage. Oct 8, 2024 · Find patient medical information for Duloxetine (Cymbalta, Drizalma Sprinkle) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings When switching from another antidepressant to Cymbalta your healthcare provider may want to lower the dose of the initial antidepressant first to potentially avoid side effects. Some of the common side effects of duloxetine will gradually improve as your body gets used to it. Suicidal thoughts or actions: Cymbalta and other antidepressant medicines may increase suicidal thoughts or actions in some children, teenagers, or young adults within the first few months of treatment or when the dose is changed. Apr 24, 2018 · Cymbalta is used to treat depression, OCD, and fibromyalgia, in addition to other conditions. Mar 3, 2025 · Duloxetine is a selective serotonin and norepinephrine reuptake inhibitor antidepressant used to treat major depressive disorder and general anxiety disorder. Learn about its more common, mild, and serious side effects and how to manage them. Learn more about its side effects, dosages, and uses here. Cymbalta (duloxetine hydrochloride) Delayed-Release Sep 26, 2025 · Withdrawal from Cymbalta can cause symptoms like nausea, headaches, and irritability. It is also used for pain caused by nerve damage associated with diabetes (diabetic peripheral neuropathy). Common brand names for this medication include Cymbalta®, Drizalma® and Irenka®. In this article, we discuss the physiological effects of Cymbalta abuse, and help you identify the possible warning signs of addiction to this drug. , labeling that is not submitted to the FDA). Taking an extra dose of Cymbalta (duloxetine) by accident can increase the risk of side effects like nausea, dizziness, or increased heart rate. If such symptoms occur, discontinue CYMBALTA and initiate supportive treatment. We experienced a patient who had taken an overdose of duloxetine (780 mg) in combination with other drugs in a suicide attempt. Dec 8, 2021 · Duloxetine (Trade name: Cymbalta) is an antidepressant in the serotonin norepinephrine reuptake inhibitor (SNRI) class used in the treatment of major depressive disorder and neuropathic pain. Learn about its common, mild, and serious side effects. In general, these weight changes are minimal and may be due to temporary side effects like nausea or loss of appetite, some of the most common side effects of Cymbalta treatment. com. 4) Dec 13, 2024 · 233,000 bottles of duloxetine, the generic name for a popular antidepressant, were recently recalled. Nov 25, 2009 · 14. Four nonfatal acute ingestions of Cymbalta (300-1400 mg), alone or in combination with other drugs have been reported. Methods: We undertook a retrospective review of duloxetine overdoses (>120 mg) admitted to two tertiary toxicology units between March 2007 and May 2021. Jun 27, 2025 · Comprehensive guide on serotonin-norepinephrine reuptake inhibitors, including their pharmacology, administration, and potential side effects. Learn about side effects it can cause and how to manage them. D. The drug has a long list of interactions, and possible side effects include nausea, increased sweating and withdrawal symptoms. It increases serotonin and norepinephrine in your brain. CYMBALTA (duloxetine delayed-release capsules), for Sep 22, 2025 · The prescription anti-depressant Cymbalta is occasionally abused by those who take it, and can sometimes lead to addiction. 10. It was one of Eli Lilly’s most profitable drugs. Jul 2, 2024 · Acute poisoning from atypical non-SSRI antidepressants, including serotonin modulators and SNRIs, requires prompt diagnosis and management to prevent severe complications. , M. Includes dose adjustments, warnings and precautions. Its chemical designation is (+)-(S)-N-methyl-γ-(1-naphthyloxy)-2-thiophenepropylamine hydrochloride. Apr 14, 2014 · 14. Secondly, Cymbalta overdose is common in settings where the medication is combined with other substances that are contraindicated to be used with Duloxetine. Feb 20, 2023 · Duloxetine, also known as Cymbalta, is an antidepressant medication, classified as a serotonin-norepinephrine reuptake inhibitor (SNRI), primarily used in the treatment of depression and generalized anxiety disorder. Case presentation The patient Cymbalta and other antidepressant medicines may cause serious side effects, including: 1. Apr 14, 2025 · This guide is adapted from the clinician guide authored by Sebastián Malleza, M. Learn about dosages, timelines, and potential side effects. Herein we present a fatal case of Apr 1, 2024 · Cymbalta is a depression and anxiety medication. 1 Major Depressive Disorder - The efficacy of Cymbalta as a treatment for depression was established in 4 randomized, double-blind, placebo-controlled, fixed-dose studies in adult outpatients Sep 22, 2025 · Learn about the side effects of duloxetine, from common to rare, for consumers and healthcare professionals. Continue reading • Keep a list of all your medicines (prescription, natural products, supplements, vitamins, over-the-counter) and give it to your healthcare provider (doctor, nurse, nurse practitioner, pharmacist, or physician assistant) What side effects could occur with duloxetine (Cymbalta®)? • Dry mouth • Nervous and excitable • Headache Feb 3, 2021 · Background Combinations of antidepressant duloxetine (at doses of 40–60 mg/day) and other antipsychotics are frequently used in clinical treatment; however, several fatal and nonfatal cases of duloxetine overdose have been documented. These medications can help prevent suicidal thoughts /attempts and provide other important benefits Find medical information for Cymbalta on epocrates online, including its dosing, contraindications, drug interactions, and pill pictures. Here are 13 side effects to know before taking Cymbalta and when to consult your prescriber. Nov 22, 2024 · Cymbalta (duloxetine) is used to treat major depressive disorder, general anxiety disorder and fibromyalgia. It has several interactions to know about. Here’s what you need to know about Cymbalta dosages for depression, anxiety, fibromyalgia, and more. 1,6 Jun 6, 2022 · Conclusion Duloxetine overdose most commonly caused sympathomimetic effects and serotonin toxicity, consistent with its pharmacology, and did not result in coma, arrhythmias or intensive care admission, when taken alone in overdose. . May 14, 2024 · Cymbalta (duloxetine) is a prescription drug for anxiety, pain from diabetic neuropathy, and other conditions. Duloxetine: learn about side effects, dosage, special precautions, and more on MedlinePlus Duloxetine (Cymbalta) is a drug prescribed for neuropathic pain associated with diabetic peripheral neuropathy, depression, and anxiety. The structural formula is: May 1, 2025 · Cymbalta is more likely to cause weight loss early in the first 8 to 9 weeks of treatment, but result in a modest weight gain after 8 months of treatment. Jul 26, 2021 · Cymbalta is a prescription drug used for certain mental health conditions and certain types of pain. In case of acute overdose, treatment should consist of those general measures employed in the management of overdose with any drug. If you need to stop the Jul 26, 2024 · Easy-to-read patient tips for Cymbalta covering how it works, benefits, risks, and best practices. Can you OD on antidepressants? An antidepressant overdose often occurs when someone takes antidepressants in large doses, attempts self-harm, or combines them with other drugs and alcohol. But most people have no side effects or only minor ones. May 30, 2019 · Given that the maximum daily dose is 120mg, it is likely that one would have enough pills available at one time to reach Duloxetine overdose. DailyMed does not contain a complete listing of labeling for FDA-regulated products (e. Apr 22, 2025 · Cymbalta’s typical starting dosage for anxiety is 60 milligrams (mg) per day for most adults and 30 mg per day for some children and older adults (ages 65 years and older). Learn about side effects, dosage, and more. What are the most common side effects of Cymbalta (duloxetine)? Side effects of Cymbalta and its generic form, duloxetine, are often mild, but can include nausea, dry mouth, dizziness, headache, sleepiness, constipation, and changes in appetite or sex drive, and more. Jun 23, 2020 · Cymbalta is a serotonin-norepinephrine reuptake inhibitor (SNRI) used to treat major depressive disorder (MDD), generalized anxiety disorder and pain conditions. Sc. While a 120 mg/day dose was shown Mar 10, 2025 · Cymbalta is an antidepressant approved to treat mood and pain disorders. If you’re experiencing side effects from this medication, contact your doctor to discuss the severity of it and what options you have moving forward. Cymbalta is used to treat depression and anxiety disorders in adolescents and adults. NHS medicines information on dosage for duloxetine, how to take it and what to do if you miss a dose or take too much. Duloxetine, sold under the brand name Cymbalta among others, [1] is a medication used to treat major depressive disorder, generalized anxiety disorder, obsessive–compulsive disorder, fibromyalgia, neuropathic pain, central sensitization, and other types of chronic pain. If a dose of CYMBALTA is missed, take the missed dose as soon as it is remembered. Apr 11, 2024 · Increasing dosages of any drug, including Cymbalta, may increase your risk of side effects. Jun 2, 2023 · Cymbalta (duloxetine) is a prescription antidepressant used to treat depression, anxiety, and some other conditions. DESCRIPTION Cymbalta® (duloxetine hydrochloride) is a selective serotonin and norepinephrine reuptake inhibitor (SSNRI) for oral administration. These interactions can cause side effects, some of which can be serious. In this article, we discuss the physiological effects of Cymbalta withdrawal, and present a variety of options for treatment. Cymbalta (duloxetine) is commonly used to treat depression and generalized anxiety. Cymbalta is used to treat or manage Major Depressive Disorder (MDD), Generalized Anxiety Disorder (GAD), Diabetic Peripheral Neuropathic Pain, Fibromyalgia, and Chronic Musculoskeletal Pain. Duloxetine Brand names: Cymbalta, Yentreve. If it is almost time for the next dose, skip the missed dose and take the next dose at the regular time. g. Learn more about side-effects and treatment from Patient. Jul 31, 2025 · Antidepressants (Prozac, Cymbalta, Wellbutrin) are a class of prescription medications used to treat depression, anxiety, and other mood disorders. 88. The drug belongs to a class of antidepressant medicines known as serotonin and norepinephrine reuptake Jul 22, 2025 · Cymbalta, which is used to treat depression, can cause side effects. Survival after massive overdose has previously been reported, however Aug 17, 2024 · Duloxetine can be used to treat a range of mood and nerve disorders such as depression and anxiety. May 16, 2025 · Cymbalta side effects vary from person to person, and it’s important to consult a doctor when starting or stopping this medication. 1 Dosage for Treatment of Major Depressive Disorder Administer CYMBALTA at a total dose of 40 mg/day (given as 20 mg twice daily) to 60 mg/day (given either once daily or as 30 mg twice daily). Duloxetine (Cymbalta) is a drug used to treat fibromyalgia and nerve pain. Apr 10, 2024 · The best Cymbalta dosage depends on your age and the condition it’s used for. May 23, 2023 · Common Cymbalta side effects may include nausea, dry mouth, insomnia, constipation, dizziness, and fatigue. Sep 22, 2025 · The prescription anti-depressant Cymbalta is occasionally abused by those who take it, and can sometimes lead to addiction. Find out how duloxetine treats depression, anxiety, nerve pain and urinary incontinence, and how to take it. May 1, 2023 · Cymbalta (Duloxetine) is a serotonin and norepinephrine reuptake inhibitor (SNRI) antidepressant used to treat depression, anxiety, and other mental health disorders. Includes dosages for Depression, Pain, Chronic Pain and more; plus renal, liver and dialysis adjustments. [9] Duloxetine is a serotonin–norepinephrine reuptake inhibitor (SNRI). It’s a prescription capsule that treats pain, anxiety, and depression. 53% of reviewers reported a positive experience, while 30% reported a negative experience. Duloxetine belongs to a group of medicines known as selective serotonin and Sep 22, 2025 · Learn about the side effects of Cymbalta (duloxetine), from common to rare, for consumers and healthcare professionals. The recall was initiated earlier this month on Oct. Oct 18, 2011 · These highlights do not include all the information needed to use Cymbalta safely and effectively. Dec 10, 2024 · DULoxetine Hydrochloride reference guide for safe and effective use from the American Society of Health-System Pharmacists (AHFS DI). Jul 21, 2025 · Detailed dosage guidelines and administration information for Cymbalta (duloxetine hydrochloride). Side effects of duloxetine Like all medicines, duloxetine can cause side effects in some people. Side effects, dosage, and drug interaction information are included. Sep 15, 2021 · The DailyMed database contains 154956 labeling submitted to the Food and Drug Administration (FDA) by companies. These are hormones that regulate your mood and pain. However, with proper use under a doctor’s or medical professional’s supervision, side effects and adverse effects often resolve, and Cymbalta can improve overall mental health and well-being over time. What is the most important information I should know about antidepressant medicines, depression, other serious mental illnesses, and suicidal thoughts or actions? Cymbalta and other antidepressant medicines may increase suicidal thoughts or actions in some children, teenagers, or young adults within the first few months of treatment or when the dose is changed. May 22, 2025 · What is duloxetine treatment for anxiety, depression, or chronic pain? Learn how Cymbalta works, plus its side effects, risks, and how to taper off safely. Includes Cymbalta side effects, interactions and indications. 3 out of 10 from a total of 1,908 reviews on Drugs. Jul 24, 2025 · Learn about duloxetine oral capsule’s side effects, how it's taken, and more. Learn about side effects, drug interactions, dosages, warnings, and more. See full prescribing information for Cymbalta. Feb 17, 2020 · Includes DULoxetine indications, dosage/administration, pharmacology, mechanism/onset/duration of action, half-life, dosage forms, interactions, warnings, adverse Mar 23, 2023 · Background: Duloxetine is a second-generation serotoninnorepinephrine reuptake inhibitor prescribed for treatment of both psychiatric disorders and neuropathic pain. These will often improve over the first week or two as y Sexual side effects, such as problems with orgasm or ejaculatory delay, and blood pressure increases often do not improve over time. [11] The precise The use of MAOIs intended to treat psychiatric disorders with CYMBALTA or within 5 days of stopping treatment with CYMBALTA is contraindicated because of an increased risk of serotonin syndrome. Oct 24, 2024 · The Food and Drug Administration has announced a recall for thousands of bottles of the antidepressant duloxetine, sold under brand names like Cymbalta, due to the presence of a chemical that can May 22, 2016 · Cymbalta (duloxetine) is an effective medication for managing chronic pain. This medication is an antidepressant that's called an SNRI or serotonin and norepinephrine reuptake inhibitor. Oct 8, 2024 · Find patient medical information for Duloxetine (Cymbalta, Drizalma Sprinkle) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings Apr 30, 2024 · Duloxetine (Cymbalta) is used to treat depression, anxiety, and some forms of long-term pain. While it can be effective in managing these conditions, an overdose of duloxetine can have serious and potentially life-threatening consequences. Jan 30, 2024 · Cymbalta may cause several side effects, including nausea, dizziness, dry mouth, fatigue, and decreased appetite. If concomitant use of CYMBALTA with other serotonergic drugs is clinically warranted, patients should be made aware of a potential increased risk for serotonin syndrome, particularly during treatment initiation and dose increases (5. Sometimes just the worry of having taken too much can amplify anxiety symptoms, especially when living with PTSD and depression. Find medical information for Cymbalta on epocrates online, including its dosing, contraindications, drug interactions, and pill pictures. Duloxetine Dec 19, 2022 · Duloxetine (Cymbalta) is a medication used to treat depression, diabetic nerve pain, and chronic pain conditions. Learn about how duloxetine works, potential side effects, dosage, alternative medications and more. It's a generic prescription drug used for various conditions, including depression. Oct 1, 2025 · Description Duloxetine is used to treat depression and anxiety. Dec 12, 2024 · More than 233,000 bottles of an antidepressant have been recalled by the FDA due to the presence of duloxetine posing the risk of cancer. It can also cause serious side effects, that in some cases require a change of medication or professional treatment. The use of CYMBALTA within 14 days of stopping an MAOI intended to treat psychiatric disorders is contraindicated [see Dosage and Administration (2. Oct 23, 2024 · The Food and Drug Administration announced a Class II recall for more than 7,000 bottles of an antidepressant due to a chemical. There are many medications, supplements, and beverages (like alcohol) that can interact with duloxetine. BRAND NAME (S): Cymbalta Warning | Medication Uses | How To Use | Side Effects | Precautions | Drug Interactions | Overdose | Notes | Missed Dose | Storage WARNING: Antidepressant medications are used to treat a variety of conditions, including depression and other mental/mood disorders. Jul 21, 2025 · These highlights do not include all the information needed to use CYMBALTA safely and effectively. Here's what to know about the medication. Learn more about Cymbalta and its side effects. Pharmacology, adverse reactions, warnings, and CYMBALTAside effects. Duloxetine is also used to treat fibromyalgia (muscle pain and stiffness) and chronic (long-lasting) pain that is related to muscles and bones. Cymbalta User Reviews & Ratings Cymbalta has an average rating of 6. It works by preventing the body from reabsorbing two neurotransmitters: serotonin and norepinephrine. Your doctor will usually start you on the lowest dosage of Cymbalta for your condition. For some patients, it may be desirable to start at 30 mg once daily for 1 week, to allow patients to adjust to the medication before increasing to 60 mg once daily. There is no specific antidote to Cymbalta. Here are the Cymbalta side effects you Sep 8, 2010 · Related topics cymbalta Further information Cymbalta uses and safety info Cymbalta prescribing info & package insert Side effects of Cymbalta Similar questions Search for questions Still looking for answers? Try searching for what you seek or ask your own question. Oct 22, 2025 · Detailed Duloxetine dosage information for adults, the elderly and children. Duloxetine (Cymbalta) is a moderately priced drug used to treat depression, anxiety, fibromyalgia, and nerve pain associated with diabetes (diabetic peripheral neuropathy). [9][10] It is taken by mouth. The dosage is typically one capsule by mouth once daily (or twice daily for some people with depression). It’s important to give your healthcare provider an accurate May 7, 2022 · Cymbalta (duloxetine) is a medication prescribed for depression and other conditions. CYMBALTA prescription and dosage information for physicians and health care professionals. Learn about side effects, dosage, uses, and more. 1 Major Depressive DisorderThe efficacy of Cymbalta as a treatment for depression was - established in 4 randomized, double-blind, placebo-controlled, fixed-dose - studies in adult outpatients Dec 30, 2020 · Learn about Cymbalta: What it is used for, how to take Cymbalta, serious side effects, food and drug interactions, forms, doses, safe storage, and FAQs. Includes: indications, dosage, adverse reactions and pharmacology. Here’s how three people describe what it feels like to take Cymbalta. Mar 6, 2025 · Cymbalta is a prescription drug for anxiety, pain from diabetic neuropathy, and other conditions. Food and Drug Administration Medscape - Generalized anxiety disorder, major depressive disorder, fibromyalgia-specific dosing for Cymbalta, Drizalma Sprinkle (duloxetine), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. Monitor for symptoms such as severe headache, confusion, or unusual behavior. See full prescribing information for CYMBALTA. Common side effects These common side effects of duloxetine can happen in up to 1 in 10 people. The typical dosage Feb 7, 2020 · Cymbalta is often prescribed to treat depression and anxiety. Even if an excessive dose does not result in poisoning, it can worsen the drug’s side effects, like weight changes on Cymbalta. If you need to stop Cymbalta, your doctor will likely come up with a plan for you to slowly lower your dose over time until it’s safe for you to stop the drug completely. Learn about its side effects and how you can manage them. Relatively few fatalities have been reported in association with its use. Learn more about withdrawal symptoms, how long it lasts, and how to get help. Apr 14, 2022 · Cymbalta (duloxetine) is a prescription tablet that treats certain types of anxiety, depression, and pain. Duloxetine overdose overall is uncommon, with a total of 6281 cases involving the drug reported in 2020 by the American Association of Poison Control Centers. Cymbalta package insert / prescribing information for healthcare professionals. Duloxetine Delayed-Release Capsules Duloxetine is a medication that treats depression, anxiety, fibromyalgia and certain types of chronic pain such as nerve, bone or joint pain. But like all drugs, it can come with dangerous consequences. Jul 25, 2021 · Learn about side effects, dosage, and more for Cymbalta (duloxetine). For the complete clinical resource, visit: Duloxetine Guide: Pharmacology, Indications, Dosing Guidelines and Adverse Effects What is Duloxetine? Duloxetine (brand name Cymbalta) is a medication that treats several conditions including depression, anxiety, and certain What are the possible side effects of duloxetine? Common side effects aving trouble sleeping (insomnia). at the Psychopharmacology Institute. Dec 10, 2015 · Abstract Duloxetine is a second-generation selective serotonin and norepinephrine reuptake inhibitor used primarily for the treatment of depression. 8 2. Similarly, there are no known reports that provide a comprehensive analysis of blood, fluid and tissue samples in an overdose setting. The empirical formula is C18H19NOS•HCl, which corresponds to a molecular weight of 333. Take this medication exactly as prescribed and consult with your doctor before starting any other medication (prescribed or over the counter) while on duloxetine, as adverse Feb 23, 2023 · Cymbalta (duloxetine) is used to treat depression, anxiety, and chronic pain. Cymbalta and other antidepressant medicines may cause serious side effects, including: 1. Duloxetine (Cymbalta®) is used to treat chronic pain from osteoarthritis and fibromyalgia, especially when other medications are ineffective. Side effects can include nausea, headache, and dry mouth. Cymbalta overdose can happen if the individual takes increased doses of the drug whether intentionally or by accident such that they may consume a fatal dose. 9o1y qh9pf5 ao8d4wv0l 8quw kgo vruxjh mh zgwjn zdsf xb89q